Bioinformatics and Functional Genomics by Jonathan Pevsner

By Jonathan Pevsner

The bestselling advent to bioinformatics and genomics – now in its 3rd edition

Widely bought in its prior variants, Bioinformatics and useful Genomics bargains the main broad-based creation to this explosive new self-discipline. Now in a completely up to date and improved 3rd version, it is still the go-to resource for college students and execs interested in biomedical research.

This ebook presents up to date insurance of the fields of bioinformatics and genomics. positive aspects new to this version include:

  • Extensive revisions and a moderate reorder of chapters for a more desirable organization
  • A fresh bankruptcy on next-generation sequencing
  • An extended spouse web site, additionally up-to-date as and whilst new details turns into available
  • Greater emphasis on a computational technique, with transparent suggestions of the way software program instruments paintings and introductions to using command-line instruments similar to software program for next-generation series research, the R programming language, and NCBI seek utilities

The ebook is complemented by way of lavish illustrations and greater than 500 figures and tables - many newly-created for the 3rd variation to augment readability and knowing. each one bankruptcy contains studying goals, an issue set, pitfalls part, packing containers explaining key strategies and mathematics/statistics ideas, a precis, instructed studying, and an inventory of freely to be had software program. Readers may perhaps stopover at a similar website for supplemental details corresponding to PowerPoints and audiovisual documents of lectures, and videocasts of the way to accomplish many simple operations:

Bioinformatics and useful Genomics, 3rd version serves as a good single-source textbook for complex undergraduate and starting graduate-level classes within the organic sciences and machine sciences. it's also an fundamental source for biologists in a huge number of disciplines who use the instruments of bioinformatics and genomics to review specific study difficulties; bioinformaticists and computing device scientists who boost desktop algorithms and databases; and clinical researchers and clinicians who are looking to comprehend the genomic foundation of viral, bacterial, parasitic, or different diseases.

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Additional resources for Bioinformatics and Functional Genomics

Example text

The complete genome sequences of thousands of organisms are now available. One of the main lessons we are learning is the fundamental unity of life at the molecular level. We are also coming to appreciate the power of comparative genomics, in which genomes are compared. Through DNA sequence analysis we are learning how chromosomes evolve and are sculpted through processes such as chromosomal duplications, deletions, and rearrangements, and through whole‐genome duplications (Chapters 8 and 18–19).

I introduce concepts in the context of biological problem‐solving. Compared to earlier editions, this new text emphasizes command‐ line software on the Linux (or Mac) platform, complemented by web‐based approaches. xxxi xxxii Preface to the third edition In an era of “Big Data” there is a great divide between those whose intellectual core is centered in biomedical science and those whose focus involves computer science. I hope this book helps to bridge the divide between these two cultures. Writing a book like this is a wonderful and constant learning experience.

I've learned from all these teachers, including Dimitri Avramopoulos, Jef Boeke, Kyle Cunningham, Garry Cutting, George Dimopoulos, Egert Hoiczyk, Rafael Irizarry, Akhilesh Pandey, Sean Prigge, Ingo Ruczinski, Alan Scott, Alan F. Scott, Kirby D. Smith, David Sullivan, David Valle, and Sarah Wheelan. I am grateful to faculty members with whom I taught genomics workshops including Elana Fertig, Luigi Marchionni, John McGready, Loris Mulroni, Frederick Tan, and Sarah Wheelan. This book includes several thousand literature references, but I apologize to the many more colleagues whose work I did not cite.

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