Computational Neurogenetic Modeling (Topics in Biomedical by Lubica Benuskova

By Lubica Benuskova

It is a pupil textual content, introducing the scope and difficulties of a brand new clinical self-discipline - Computational Neurogenetic Modeling (CNGM). CNGM is worried with the examine and improvement of dynamic neuronal types for modeling mind features with appreciate to genes and dynamic interactions among genes. those comprise neural community versions and their integration with gene community versions. This new region brings jointly wisdom from numerous medical disciplines.

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2. Consolidation. The process of stabilization of new information, transformation into a long-term memory by means of rehearsal. 3. Storage. Long-term storing of information in memory. 4. Recall. Retrieval of information into the working memory. Based on clinical, imaging and animal studies we can divide long-term memory into two main categories that have different subtypes with different mechanisms and different localizations in the brain (Fig. 1). Explicit (declarative) memory is a memory of facts (semantic memory) and a memory of events (episodic memory).

2 degrees of Kelvin) necessary for the MEG's SQUIDS to be able to measure these brain magnetic fields that are billions of times weaker than the earth's magnetic force. Investigators use MEG to measure magnetic changes in the active, functioning brain in the speed of milliseconds. Besides its precision another advantage of MEG is that the biosignals it measures are not distorted by the body as in EEG. Used in conjunction with MRI or fMRI (see below), to relate the MEG sources to brain anatomical structures, researchers can localize brain activity and measure it in the same temporal dimension as the functioning brain itself.

Requires an invasion into the brain and into the brain cells. Moreover, without post-mortem histology, it is almost impossible to tell where exactly the recordings were actually made from. Classical anatomical methods, by means of which Cajal and other pioneers made their discoveries, are histology and staining. Anatomists still use to dissect dead brains, stain their cells with different dyes (Golgi stain, lucifer yellow, etc), and study them under the microscope. Thus they can reveal the microscopic structure of the brain in terms of cell types and neural connectivity between cells.

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