Crystal-Induced Arthropathies: Gout, Pseudogout and by Robert L. Wortmann, H. Ralph Schumacher, Michael A. Becker,

By Robert L. Wortmann, H. Ralph Schumacher, Michael A. Becker, Lawrence M. Ryan

Divided into 5 expansive sections, this advisor presents an in-depth assessment of crystal-induced arthritis and comparable problems. delivering a old viewpoint all through, this paintings contains distinct descriptions of the medical good points of those illnesses, in addition to a present evaluation in their id, epidemiology, genetics, and underlying pathophysiology. This authoritative advisor additionally studies case reports, present diagnostic instruments, and the superiority of those stipulations whereas introducing new and rising treatments for sickness administration.

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Lehto S, Niskanen L, Ronnemaa T, Laakso M. Serum uric acid is a strong predictor of stroke in patients with non-insulin-dependent diabetes mellitus. Stroke 1998; 29:635–639. 101. Anker SD, Doehner W, Rauchhaus M, et al. Uric acid and survival in chronic heart failure: validation and application in metabolic, functional, and hemodynamic staging. Circulation 2003; 107:1991–1997. 102. McCarty DJ, Jr. Crystal-induced inflammation; syndromes of gout and pseudogout. Geriatrics 1963; 18:467–478. 103. Rosenthal AK, Ryan L.

127. Fernandez Dapica MP, Gomez-Reino JJ. Familial chondrocalcinosis in the Spanish population. J Rheumatol 1986; 13:631–633. 128. Andrew LJ, Brancolini V, de la Pena LS, et al. Refinement of the chromosome 5p locus for familial calcium pyrophosphate dihydrate deposition disease. Am J Hum Genet 1999; 64:136–145. 129. Doherty M, Hamilton E, Henderson J, Misra H, Dixey J. Familial chondrocalcinosis due to calcium pyrophosphate dihydrate crystal deposition in English families. Br J Rheumatol 1991; 30:10–15.

Pyrazinamide, ethambutol, and niacin are associated with gout due to their suppressive effects on uric acid secretion. GOUT COMORBIDITIES, OTHER ASSOCIATIONS, AND PROGNOSIS Metabolic Syndrome The metabolic syndrome (previously referred to as syndrome X) is a highly prevalent condition defined by high fasting glucose, abdominal obesity, hypertriglyceridemia, low HDL-C, hypertension, and increased risk for atherosclerotic events (68). The metabolic syndrome, as well as its components, is independently associated with hyperuricemia, and evidence supporting these associations are reviewed individually below.

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